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Beaumont Laboratory

CAH Profile 6 (Comprehensive Screen)

LabCorp #500175, Esoterix #500865, EPIC: LAB5986, SOFT: XCAH6


  • This profile includes: Androstenedione, Cortisol, Deoxycorticosterone (DOC), DHEA, Progesterone, Specific Compound S, Testosterone, 17-OH-Pregnenolone, 17-A-OH-Progesterone.
  • A number of drugs are known to influence endocrine function directly, or to interfere with assay methodology. Whenever possible, physicians should consider discontinuing all drugs, except those necessary to the patient's well-being, several days prior to sample collection. Always note any drugs being administered on the Test Request Form. 

Specimen Collection Criteria

Collect: Three plain Red-top tubes.

Do not use Serum Separator Tubes.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within one hour of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 3.5 mL serum, frozen (-20°C/-4°F or below). (Min: 2.0 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Specimens not collected and processed as indicated. 


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): 24 hours
Frozen (-20°C/-4°F or below): 90 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to LabCorp Esoterix Endocrinology, Calabassas Hills, CA.


Monday, Wednesday.
Results available in 5-9 days.

Reference Range

By report.

Test Methodology

High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS).

Clinical Utility

The Clinical CAH Profile 6 (Comprehensive Screen) measures these adrenal glucocorticoid and androgen steroid pathways to identify the specific enzymatic deficiency(ies) of neonates born with ambiguous genitalia. The prime diagnosis until it is ruled out is congenital adrenal hyperplasia (21-hydroxylase deficiency), because CAH is the only condition which is potentially life threatening.

The external genitalia are rarely distinctive enough to allow diagnosis of a particular disorder or to distinguish clearly between male and female pseudohermaphroditism. The potential for a grave error in diagnosis and subsequent management emphasizes the need for adequate biochemical characterization of the defect in each patient with ambiguous genitalia.

CPT Code

82157, 82533, 82626, 82633, 82634, 83498, 84143, 84144, 84403.

Test Codes

LabCorp #500175, Esoterix #500865, EPIC: LAB5986, SOFT: XCAH6

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.