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Beaumont Laboratory


Cryofibrinogen, Plasma, Antrim #15502, EPIC: LAB5827, SOFT: CRYOP


  • Blood must ONLY be collected at the Grosse Pointe, Royal Oak, or Troy hospitals campuses. It should NOT be collected at any other Beaumont Lab draw site.
  • Blood must only be collected Monday - Friday, 6:00 a.m. - 3:00 p.m.
  • Ideally patients should be fasting for 9-12 hours prior to blood collection, however this is not absolutely essential and non-fasting samples will be accepted. 

Specimen Collection Criteria

Collect: Two Lavender-top EDTA tubes and one plain Red-top tube, pre-warmed and transported at 37°C.

NOTE: If Cryoglobulin testing is ordered with Cyrofibrinogen, the Red-top tube does not need to be drawn for the Cyrofibrinogen.

Rejection Criteria

  • Samples not kept at 37°C from the time of collection to receipt in the Laboratory.
  • Severely lipemic samples. 


Grosse Pointe specimens sent to Royal Oak Special Testing Laboratory
Royal Oak Special Testing Laboratory
Troy Chemistry Laboratory


Collected: Monday - Friday, 6:00 a.m. - 3:00 p.m.
Results available in 7 days.

Reference Range


Test Methodology



Lipemia interferes with assay.

Heparin should not be used as an anticoagulant in this assay. Small amounts of cold precipitable protein are frequently observed in the plasma of normal subjects and in the plasma of patients with an acute febrile illness when heparin is used.

Clinical Utility

Cryofibrinogenemia in excess of 100 mg/dL of plasma may be associated with sensitivity to cold, Raynaud's syndrome, ischemic cutaneous lesions, purpura, epistaxis, and a tendency to thrombosis. It has also been observed in patients with metastatic malignant disease, particularly in metastatic carcinoma of the prostate and occasionally in patients with other diseases such as leukemia, lymphoma, collagen disease, and primary thromboembolic disease. Primary idiopathic cryofibrinogenemia has also been described.

Test Codes

Antrim #15502, EPIC: LAB5827, SOFT: CRYOP

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.