UGT1A1 Genotyping for Gilbert/Irinotecan
UDP Glucuronosyltransferase 1A1 Genotyping, Gilberts, Irinotecan, ARUP: #51332, EPIC: LAB6927, SOFT: XGUGT
Specimen Collection Criteria
Collect (preferred specimen): One Lavender-top EDTA or Yellow-top ACD tube.
Also acceptable: Extracted DNA (50 ng/mcL).
Note: This test should NOT be used for patients suspected of Crigler-Najjar syndrome.
Physician Office/Drawsite Specimen Preparation
Do not centrifuge. Maintain whole blood in original collection tubes, at refrigerated temperature (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 3.0 mL whole blood, at room temperature (20-26°C or 68-78.8°F). (Min: 1.0 mL)
- Centrifuged specimens.
- Frozen specimens.
- Specimens not collected and processed as indicated.
- This test will only be performed once in a lifetime for a patient.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.
Sent to ARUP Laboratories, Salt Lake City, UT.
Results available in 3-8 days.
Polymerase Chain Reaction (PCR)/Fragment Analysis.
- The genotyping test helps identify patients at risk for Irinotecan toxicity. UGT1A1 genotyping is also used for the diagnosis of Gilbert syndrome.
- The test is recommended on patients to be treated with chemotherapy regimens including Irinotecan (Camptosar). The test is also recommended in patients with unconjugated hyperbilirubinemia.
ARUP: #51332, EPIC: LAB6927, SOFT: XGUGT
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.