Lab results are too important to go anywhere else

Beaumont Laboratory

UGT1A1 Genotyping for Gilbert/Irinotecan

UDP Glucuronosyltransferase 1A1 Genotyping, Gilberts, Irinotecan, ARUP: #51332, EPIC: LAB6927, SOFT: XGUGT

Specimen Collection Criteria

Collect (preferred specimen): One Lavender-top EDTA or Yellow-top ACD tube.
Also acceptable: Extracted DNA (50 ng/mcL).

Note: This test should NOT be used for patients suspected of Crigler-Najjar syndrome.

Physician Office/Drawsite Specimen Preparation

Do not centrifuge. Maintain whole blood in original collection tubes, at refrigerated temperature (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 3.0 mL whole blood, at room temperature (20-26°C or 68-78.8°F). (Min: 1.0 mL)

Rejection Criteria

  • Centrifuged specimens.
  • Frozen specimens.
  • Specimens not collected and processed as indicated.
  • This test will only be performed once in a lifetime for a patient.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Monday, Thursday.
Results available in 3-8 days. 

Reference Range

By report.

Test Methodology

Polymerase Chain Reaction (PCR)/Fragment Analysis.


By report.

Clinical Utility

  • The genotyping test helps identify patients at risk for Irinotecan toxicity. UGT1A1 genotyping is also used for the diagnosis of Gilbert syndrome.
  • The test is recommended on patients to be treated with chemotherapy regimens including Irinotecan (Camptosar). The test is also recommended in patients with unconjugated hyperbilirubinemia.

CPT Code


Test Codes

ARUP: #51332, EPIC: LAB6927, SOFT: XGUGT

Last Updated


Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.