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Wellbutrin

Wellbutrin^®, Bupropion

Test Codes

EPIC: LAB6186, Beaker: XWELL, ARUP: 2010357

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tubes.
Also acceptable: Two Lavender-top EDTA tubes.

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Critical frozen. Send specimens to the Laboratory immediately after collection. Separate samples must be submitted when multiple tests are ordered.

Physician Office/Draw Specimen Preparation

Critical frozen. Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 2.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Minimum: 0.5 mL)

Rejection Criteria

• Serum Separator (SST) tubes.
• Whole Blood
• Light blue(citrate) tube
• ACD tube
• Specimens not collected and processed as indicated.

In-Lab Processing

Critical frozen. Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Transport: 2.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Minimum: 1.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday.
Results available in 2-6 days.

Reference Range

Therapeutic Range: 10-100 ng/mL.
Toxic Range: Greater than 400 ng/mL.

Test Methodology

Quantitative Liquid Chromatography – Tandem Mass Spectrometry.

Interpretation

The therapeutic range is not well established. Patient response appears to improve with concentrations between 50 and 100 ng/mL. Levels below 25 ng/mL may have no effect. Poor response and increased toxicity have been reported at concentrations above 100 ng/mL.

Clinical Utility

Wellbutrin® (Bupropion) is indicated for the treatment of depression. This assay is used for the therapeutic monitoring and toxicity assessment of Wellbutrin® (Bupropion).

CPT Codes

80338, (Alt. G0480).
LOINC:  6706-6

Contacts

Last Updated

10/3/2023