von Willebrand Antigen, Multimeric

von Willebrand Factor Multimer Analysis, Multimeric Analysis, vWF Multimer, vWF, vW Factor Multimeric

Test Codes

EPIC: LAB1232257, Beaker: VWIII Multim, Quest: 5168

Department

Send Outs

Instructions

A copy of Ristocetin Cofactor, von Willebrand Factor Antigen, and Factor VIII Activity are required to be sent with the specimen. Multimer analysis will only be performed when Ristocetin Cofactor or von Willebrand Factor Antigen are below normal.

Specimen Collection Criteria

Collect: One Light Blue-top Sodium Citrate tubes. Mix gently by inverting 3-4 times.

TUBES MUST BE FULL.

Physician Office/Draw Specimen Preparation

Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze (-20°C/-4°F or below)  immediately and transport.

Preparation for Courier Transport

Transport: 1.0 mL platelet poor plasma (PPP) aliquot, frozen (-20°C/-4°F or below). (Minimum: 0.2 mL)

Rejection Criteria

• Grossly hemolyzed specimens.
• Grossly icteric specimens.
• Grossly lipemic specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.

Transport: 1.0 mL platelet poor plasma (PPP) aliquot, frozen (-20°C/-4°F or below). (Minimum: 0.2 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Monday – Friday.
Results available in 4-8 days.

Reference Range

Normal.

Test Methodology

Electrophoresis

Interpretation

By report.

Clinical Utility

von Willebrand Antigen, Multimeric – von Willebrand Disease is the most common hereditary bleeding disorder and it may also be acquired. Von Willebrand Factor (VWF) is critical for normal hemostasis; mediating platelet adhesion to the damaged endothelium and protecting Factor VIII from proteolytic degradation in circulation. VWF Multimeric Analysis is used to assist in categorizing disease subtype.

CPT Codes

85247
LOINC:  48595-3

Contacts

Last Updated

12/19/2025