Riboflavin (Vitamin B2), Plasma
Riboflavin, Vitamin B2
Test Codes
EPIC: LAB3216, Beaker: XVTB2, MAYO: VITB2
Department
Send Outs
Instructions
The patient must be fasting 12-14 hours prior to specimen collection (for infants, collect specimen just prior to next schedule feeding).
Specimen Collection Criteria
Collect: One Dark Green-top Lithium or Sodium Heparin tube.
Also acceptable: Light-green top (sodium or lithium heparin plasma gel).
- Protect specimen from light.
- Send specimen for processing immediately after collection.
Physician Office/Draw Specimen Preparation
Protect specimen from light. Centrifuge to separate plasma from cells within 2 hours of collection. Transfer plasma to an amber plastic transport tube and freeze (-20°C/-4°F or below).
Preparation for Courier Transport
Transport: 2.0 mL light-protected plasma, frozen (-20°C/-4°F or below). (Minimum: 0.50 mL)
Rejection Criteria
- Specimens not protected from light.
- Grossly lipemic specimens.
- Grossly icteric specimens
- Specimens not collected and processed as indicated.
In-Lab Processing
Protect specimen from light. Centrifuge to separate plasma from cells within 2 hours of collection. Transfer plasma to an amber plastic transport tube and freeze (-20°C/-4°F or below).
Transport: 2.0 mL light-protected plasma, frozen (-20°C/-4°F or below). (Minimum: 0.50 mL)
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.
Laboratory
Sent to Mayo Medical Laboratories, Rochester, MN.
Performed
Monday, Wednesday, Friday
Results available 3-5 days.
Reference Range
By report.
Test Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
Interpretation
By report.
Clinical Utility
The Vitamin B2 (Riboflavin) assay aids in the evaluation of patients with ariboflavinosis and in patients who present with chronic, progressive nerve compression disorders such as carpal or tarsal tunnel syndrome.
Ariboflavinosis is the dietary deficiency of Vitamin B2 (Riboflavin). This deficiency causes a syndrome characterized by sore throat, hyperemia, and edema of the pharyngeal and oral mucous membranes, cheilitis, angular stomatitis, glossitis, corneal vascularization, dyssebacia with dermatitis, and normochromic normocytic anemia.
Deficiencies of riboflavin and vitamin B6 have been suggested as potentiating factors for chronic progressive nerve compression disorders, such as carpal tunnel syndrome.
CPT Codes
84252
LOINC: 2924-9
Contacts
Send Outs Laboratory – RO
248-551-9045
Name: Send Outs Laboratory – RO
Location:
Phone: 248-551-9045
Last Updated
12/3/2024
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