Zinc Protoporphyrin (ZPP), Whole Blood
Test Codes
Warde: ZPP, EPIC: LAB6352, Beaker: XZPIN
Specimen Collection Criteria
Collect (preferred specimen): One Royal Blue-top EDTA tube.
Also acceptable: One Lavender-top EDTA tube.
- Must protect specimen from light.
Physician Office/Draw Specimen Preparation
Do not centrifuge or freeze. Maintain whole blood light protected and refrigerated (2-8°C or 36-46°F) prior to transport.
Preparation for Courier Transport
Transport: 1.0 mL whole blood, light protected and refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)
Rejection Criteria
- Specimens not protected from light.
- Frozen specimens.
- Clotted specimens.
- Hemolyzed specimens.
- Specimens not collected and processed as indicated.
In-Lab Processing
Do not centrifuge or freeze. Maintain whole blood light protected and refrigerated (2-8°C or 36-46°F) prior to transport.
Transport: 1.0 mL whole blood, light protected and refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 8 days
Refrigerated (2-8°C or 36-46°F): 8 weeks
Frozen (-20°C/-4°F or below): Unacceptable
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.
Laboratory
Sent to Warde Medical Laboratory, Ann Arbor, MI.
Performed
Tuesday, Thursday.
Results available in 4-6 days.
Reference Range
By report.
Test Methodology
Quantitative Hematofluorometry.
Interpretation
For occupational exposure to lead, OSHA requires ZPP whole blood testing reported in units of mcg/dL. For adults, conversion of ZPP units of mcg/dL assumes a hematocrit of 45%.
Clinical Utility
Elevated ZPP results are seen in early and late iron deficiency, in the anemia of chronic disease erythropoietic protoporphyria, and in chronic lead poisoning (typically when blood lead is greater than 25 mcg/dL). Causes for false elevations include markedly elevated bilirubin and riboflavin. Elevated protoporphyrin (as in erythropoietic protoporphyria) can also increase the ZPP signal. Specimens which are hemolyzed, clotted, or improperly aliquoted can also show false elevations.
CPT Codes
84202
Contacts
Send Out Laboratory – RO
248-551-9045
Name: Send Out Laboratory – RO
Location:
Phone: 248-551-9045
Last Updated
11/18/2020
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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.