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Oligoclonal Banding

MS Panel, Multiple Sclerosis Panel, CSF Protein Electrophoresis, Protein Electrophoresis CSF, IgG Index, IgG Synthesis Rate

Test Codes

EPIC: LAB6118, Beaker: XOLIG, ARUP: 80440

Department

Send Outs

Instructions

• Testing requires both CSF and serum. Collect serum within 48 hours of CSF collection.
• This test includes: Albumin, Immunoglobulin G, IgG Index, IgG Synthesis Rate and Oligoclonal Bands.

Specimen Collection Criteria

Collect: Cerebrospinal Fluid (CSF) AND Blood.

• Cerebrospinal Fluid: 1.5 mL CSF in a sterile collection container. (Minimum: 1.0 mL)
• Blood: One Gold-top SST tube or one plain Red-top tube. (Minimum: 0.6 mL)

Blood sample MUST be drawn within 48 hours of CSF collection. Specimens need to be assayed together for interpretation.

Physician Office/Draw Specimen Preparation

Let blood specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F). Maintain CSF refrigerated prior to transport.

Preparation for Courier Transport

Transport: 1.5 mL CSF and 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.7 mL CSF and 0.5 mL serum)

Rejection Criteria

Submissions that do not include both a CSF and serum specimen will not be tested.

• Specimens not collected and processed as indicated.
• Grossly bloody, severe lipemia, hemolyzed.

In-Lab Processing

Let blood specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F). Maintain CSF refrigerated prior to transport.

Transport: 1.5 mL CSF and 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.7 mL CSF and 0.5 mL serum)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 2 weeks
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Sunday – Saturday.
Results available in 2-5 days.

Reference Range

By report.

Test Methodology

Qualitative Isoelectric Focusing, Electrophoresis, and Quantitative Immunoturbidimetry.

CPT Codes

82040, 82042, 82784 x2, 83916.
LOINC:  56974-9, 12782-9, CSF IgG / Albumin Ratio 2470-3

Contacts

Last Updated

10/3/2023