Lab Test

Tricyclic Antidepressant (TCA) Screen, Urine

Elavil, Aventyl, Pamelor, Tofranil, Norpramin, Sinequan, Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin

Test Codes




Specimen Collection Criteria

Collect: 30 mL random urine in a sterile collection container.

Physician Office/Draw Specimen Preparation

Maintain specimen refrigerated (2-8 oC or 36-46 oF) prior to transport.

Preparation for Courier Transport

Transport: Urine in a sterile collection container, refrigerated (2-8°C or 36-46°F). (Min: 15 mL urine)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Deliver the urine sample in its original container immediately to the appropriate testing station.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 8 hours
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 2 months


Royal Oak Toxicology Laboratory


Sunday - Saturday, 24 hours a day.
STAT results available within 4 hours of receipt in the Laboratory.
Routine results available within 24 hours.

Reference Range


Test Methodology

Gas Liquid Chromatography/Mass Spectrometry. (GC/MS).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.


This assay screens urine for the presence of the following drugs: Amitriptyline, NortriptylineImipramine, Desipramine, Doxepin, Clomipramine, Trimipramine and metabolites.

Serum quantitation of these drugs is available as a separate request.

Clinical Utility

This assay is designed primarily for the detection of toxic concentrations of tricyclic antidepressants.

CPT Codes

LOINC: 19312-8, Amitriptyline 3333-2


Last Updated


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