TRAb (TSH Receptor Binding Antibody)

TSH Receptor Ab, TSH-Binding Inhibiting Immunoglobulin, Thyrotropin Receptor Antibody (TRAb), Thyrotropin Receptor Antibody, Serum

Test Codes

EPIC: LAB1232041, Beaker: TBII, Quest: 38683

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30 minutes then centrifuge to separate serum from cells within 1 hours of collection. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Rejection Criteria

• Grossly hemolyzed specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30 minutes then centrifuge to separate serum from cells within 1 hours of collection. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Transport: 1.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Tuesday, Thursday, Saturday.
Results available in 3-5 days.

Reference Range

≤2.00 IU/L

Test Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Clinical Utility

TRAb (TSH Receptor Binding Antibody) – Measurement of TRAb is used to diagnose and manage Graves' disease, neonatal hypothyroidism, and postpartum thyroid dysfunction. TRAb, which measures the ability of antibodies to inhibit TSH binding to its receptor, reflects the presence of either or both the stimulatory and inhibitory immunoglobulin classes.

CPT Codes

83520

Contacts

Last Updated

2/9/2026