Thyroglobulin, LC/MS/MS

Thyroglobulin by Mass Spectrophotometry

Test Codes

EPIC: LAB1232153, Beaker: THYROGLOB, Quest: 90810

Department

Send Outs

Specimen Collection Criteria

Collect: One Gold-top (SST) tube.

Also Acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Rejection Criteria

• Plasma specimens.
• Hemolysis.
• Icteric specimens.
• Grossly hemolyzed specimens.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F).

Transport: 1.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 6 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Saturday – Thursday.
Results available in 2-4 days.

Reference Range

Athyrotic

<0.4 ng/mL

Test Methodology

Chromatography / Mass Spectrometry

Interpretation

By report.

Clinical Utility

Thyroglobulin, LC/MS/MS – Measurement of thyroglobulin (Tg) is useful in the detection of residual or recurrent thyroid cancer. Many individuals develop auto-antibodies to Tg (Tg Ab) and the presence of Tg Ab interferes with the measurement of immunoassay Tg. The LC/MS/MS assay will provide quantitative measurement of Tg in the presence of Tg Ab.

CPT Codes

84432

Contacts

Last Updated

12/17/2025