SARS-CoV-2 IgG (Anti-Spike)
Coronavirus, Corona, corona, Covid, covid, Covid-19
Test Codes
SOFT: CVIG2, EPIC: LAB7955, SunQuest: CVIGG2, EPIC: LAB03876
Specimen Collection Criteria
Collect (preferred specimen): One Gold-top SST tube. (Minimum Whole Blood: 4.0 mL)
Physician Office/Draw Specimen Preparation
Let SST specimens clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged SST tube within two hours of collection. (Minimum: 2.0 mL)
Preparation for Courier Transport
Transport: Centrifuged SST tube or serum aliquot, refrigerated (2-8°C or 36-46°F). (Minimum: 2.0 mL serum)
Rejection Criteria
- Hemolyzed specimens.
- Severely lipemic specimens.
- Specimens with obvious microbiological contamination
In-Lab Processing
Let SST specimens clot 30-60 minutes. Centrifuge SST or Microtainers® to separate serum from cells. Deliver immediately to the appropriate testing station.
Storage
Specimen Stability for Testing:
Centrifuged SST Tubes and Microtainers® with Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable
Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 7 days
Specimen Storage in Department Prior to Disposal:
Refrigerated (2-8°C or 36-46°F): 7 days
Laboratory
Royal Oak Automated Chemistry Laboratory
Performed
Monday – Friday.
Results available within 3-5 days of receipt by the Laboratory.
Reference Range
Negative.
Test Methodology
ELISA (EUROIMMUN).
Interpretation
Presence of IgG antibodies to the spike protein of SARS-CoV-2 is a measure of immunological responsiveness to a previous viral exposure. Spike-specific antibodies can also be produced secondary to COVID-19 vaccination. A positive test result cannot be used to discriminate between an antibody response caused by a natural infection vs. vaccination.
Antibody test result should always be interpreted together with clinical history and other results such as direct viral detection of SARS-CoV-2 (COVID-19). The performance characteristics of the EUROIMMUN test were determined by Beaumont Laboratory. The test has been has been issued Emergency Use Authorization by the US Food and Drug Administration.
Clinical Utility
- Provide evidence of past exposure to SARS-CoV-2. Most individuals diagnosed with COVID-19 seroconvert within 3 weeks of exposure to the virus. If a specimen is collected too early (i.e. prior to seroconversion), the test will yield a negative result.
- Provide evidence of antibody responsiveness to COVID-19 vaccination. It is not recommended to test for spike-specific antibodies until at least 3 weeks post-vaccination.
- The SARS-CoV-2 IgG assay is not a diagnostic test. Direct viral detection assays that employ molecular methods such as nucleic acid amplification, are the only laboratory tests that are diagnostic for COVID-19.
- IgG results should not be used to make decisions on infection status
Incubation Period
According to estimates from the World Health Organization (WHO), the incubation period for SARS-CoV-2 ranges from 2-14 days with a median incubation period of 5 days.
CPT Codes
86769
LOINC 94507-1
Contacts
Automated Chemistry Laboratory – RO
248-551-8065
Name: Automated Chemistry Laboratory – RO
Location:
Phone: 248-551-8065
Last Updated
4/10/2021
Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.
This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.