Procainamide

Pronestyl, Acecainide, NAPA, Procainamide and N-Acetylprocainamide (NAPA), Procainamide Level (including NAPA), Procainamide and N-acetylprocainamide, Serum

Test Codes

EPIC: LAB1232208, Beaker: PROCAINAMIDE, Quest: 743

NOTE: Testing includes: Procainamide, N-acetylprocainamide, and Procainamide, Total

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.

Also acceptable: One Green-top sodium heparin or lithium heparin.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum or plasma from cells. Transfer serum or plasma to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.2 mL)

Rejection Criteria

• Serum separator tube (SST).
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F).

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.2 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Undetermined

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Monday – Saturday.
Results available in 2-4 days.

Reference Range

By report.

Test Methodology

Immunoassay (IA)

Interpretation

By report.

Clinical Utility

Procainamide is used to treat a variety of atrial and ventricular arrhythmias. Metabolism of procainamide produces an active metabolite N-Acetylprocainamide (NAPA). The concentration of both procainamide and NAPA levels are monitored to assure adequate therapeutic levels of procainamide are achieved and to avoid toxicity.

CPT Codes

80192

Contacts

Last Updated

12/19/2025