Lab Test

Verify Now P2Y12

Test Codes





This test is available only to patients drawn on the Dearborn and Royal Oak Hospital campuses.

Specimen Collection Criteria

Collect: Two Greiner Light Blue-top 3.2% Sodium Citrate tubes.

  • Venipuncture should be performed using a 21G or larger needle (20G or 19G). Use of a butterfly collection device is not recommended.
  • First collect a clearing tube (at least 2 mL) making sure the clearing tube does not contain any platelet inhibiting substances (e.g. EDTA).
    • Clearing tube does not need to be sent to the lab.
  • Tubes must be HAND-DELIVERED to the Coagulation Laboratory immediately. Do NOT send through the pneumatic tube system.

Preparation for Courier Transport

Transport: Whole blood at room temperature (20-26°C or 68-78.8°F).

Rejection Criteria

  • Specimens collected in BD light blue top 3.2% Sodium Citrate tubes.
  • Specimens collected in Serum Separator (SST) or Heparin tubes.
  • Specimens collected at sites other than Dearborn or Royal Oak Hospital campuses.
  • Glass tubes and 3.8% Sodium Citrate tubes.
  • Specimens that are clotted or grossly hemolyzed.
  • Inappropriate specimen volume.
  • Specimens received in the Laboratory more than 4 hours past the time of collection.

Inpatient Specimen Preparation

Hand-deliver specimens to the Laboratory immediately after collection DO NOT use the pneumatic tube system.

In-Lab Processing

Do not refrigerate or freeze specimens. Do not centrifuge. Specimens must be analyzed within 4 hours of collection.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Room Temperature (20-26 C or 68-78.8 F): 5 days
Refrigerated (2-8°C or 36-46°F): 5 days


Dearborn Hematology Laboratory
Royal Oak Coagulation Laboratory


Sunday – Saturday, 24 hours a day.
Results available within 4 hours of receipt in the Laboratory.

Reference Range

Verify Now P2Y12 assay results are reported in Platelet Reactivity Units (PRU).

Patients with PRU values at or above 208 may proceed to cardiac surgery.

Patients with PRU values below 208 should have Verify Now P2Y12 repeated in 12-24 hours. 

Test Methodology

Point of Care, utilizing platelet induced aggregation turbimetric optical detection.


Lower PRU values are indicative of effective antiplatelet drug inhibition of platelet activity.

Higher PRU values are indicative of ineffective antiplatelet drug inhibition of platelet activity.

Patients on chronic clopidogrel (Plavix) therapy with PRU values at or below 180 are considered adequate responders.  


This is a test for P2Y12 inhibition by clopidogrel (Plavix), prasugel (Effient), or ticlopidine (Ticlid). Direct IIb/IIIa inhibitors will interfere. In addition, the P2Y12 test must not be performed within 48 hours after administration of eptifibatide (Integrilin) or tirofibrin (Aggrastat), or within 14 days after administration of abciximab (ReoPro). 

CPT Codes


LOINC: 49010-2


Last Updated


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