Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G

PAI-1 4G/5G Polymorphism, PAI-1 Promoter Polymorphism, Plasminogen Activator Inhibitor-1, PAI-1 (Plasminogen Activator Inhibitor-1)

Test Codes

EPIC: LAB1231988, Beaker: PAI1 4G/5G, Quest: 11368

Department

Send Outs

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube.
Also acceptable: One Pink-top EDTA tube. 

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood at room temperature (20-26°C or 68-78.8°F). Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

Storage

Whole Blood
Room Temperature (20-26°C or 68-78.8°F): 8 days
Refrigerated (2-8°C or 36-46°F): 8 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Wednesday, Saturday.
Results available in 7-10 days.

Reference Range

By report.

Test Methodology

Polymerase Chain Reaction (PCR) and detection.

Interpretation

The PAI-1 promoter 4G/5G polymorphism located in the promoter region of the SERPINE1 gene.

Clinical Utility

Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G - Plasma plasminogen activator inhibitor, PAI-1 is a major inhibitor of fibrinolysis. The 4G variant (AF386492.2:g.837del) in the PAI-1 (Serpine 1) gene promoter region is associated with an increase in the level of PAI-1 in plasma. Increased levels of PAI-1 in plasma may increase the risk for arterial and venous thrombosis, myocardial infarction, and progression of atherosclerosis and also recurrent spontaneous abortion.

CPT Codes

81400

Contacts

Last Updated

11/19/2025