Phospholipase A2 Receptor (PLA2R) Antibody, IFA

Primary Membranous Nephropathy, Membranous Nephropathy, Glomerulonephritis, Anti-PLA2R, Idiopathic Membranous Nephropathy, PLA2R Antibodies

Test Codes

EPIC: LAB1231937, Beaker: PLA2R, Quest: 39246

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and keep at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL serum, keep at room temperature (20-26°C or 68-78.8°F) prior to transport. (Minimum: 0.5 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and keep at room temperature (20-26°C or 68-78.8°F) prior to transport.

Transport: 1.0 mL serum, keep at room temperature (20-26°C or 68-78.8°F) prior to transport. (Minimum: 0.5 mL)

Storage

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Tuesday, Thursday, Saturday.
Results available in 3-6 days.

Reference Range

Negative.

Test Methodology

Immunofluorescence Assay (IFA)

Clinical Utility

Phospholipase A2 Receptor (PLA2R) Antibody, IFA - Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. PLA2R Ab is a highly specific biomarker for PMN and is detected in about 70-80% of patients. Moreover, PLA2R Ab levels frequently rise and fall with the clinical course of PMN and PLA2R Ab levels may have clinical utility in monitoring PMN patients for therapeutic response, remission, and disease relapse.

CPT Codes

86255
LOINC: 82991-1

Contacts

Last Updated

11/19/2025