Lab Test

Oxycodone Screen, Urine

Oxycontin, Oxynorm, Roxicodone, Endocet, Endodan, Percocet, Percodan, Roxicet, Tylox, Numorphan, Opana

Test Codes


Specimen Collection Criteria

Collect: 50 mL random urine in a screw-capped container (preferred) or other sterile collection cup with no preservative. (Minimum: 30 mL)

  • Refrigerate the specimen immediately after collection.
  • Record the exact time of specimen collection on the container or in the computer system.

Physician Office/Draw Specimen Preparation

Maintain specimen refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: 50 mL urine, refrigerated (2-8°C or 36-46°F). (Minimum: 30 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.
  • Urine Vacutainer® tubes. Urine received in a glass or plastic tube with a rubber stopper may contain insufficient sample volume, preclude confirmatory testing, and give rise to contaminants and artifacts. 

In-Lab Processing

Analyze specimen immediately upon receipt in the Laboratory.


Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 1 months


Canton Laboratory
Dearborn Chemistry Laboratory
Farmington Hills Chemistry Laboratory
Grosse Pointe Chemistry Laboratory
Lenox Main Laboratory
Livonia Main Laboratory
Royal Oak Automated Chemistry Laboratory
Royal Oak Toxicology Laboratory
Troy Chemistry Laboratory
Taylor Chemistry Laboratory
Trenton Chemistry Laboratory
Wayne Chemistry Laboratory

NOTE: Screens are performed at Canton, Dearborn, Grosse Pointe, Lenox, Livonia, Royal Oak, Farmington Hills, Taylor, Trenton, Troy and Wayne. All confirmations are performed at Royal Oak. 


Sunday – Saturday, 24 hours a day.
STAT results (screen) available within 1 hour of receipt in the Laboratory, confirmation within 36 hours.
Routine results available within 48 hours.

Reference Range

Positive cutoff: 100 ng/mL.

Test Methodology

Screen: Immunoassay.
Confirmation: Liquid Chromatography/ Tandem Mass Spectrometer (LC/MS/MS).

The confirmation component of this test was developed by Beaumont Health. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.


Oxycodone and oxymorphone will produce positive results. Other opioids (morphine, codeine, hydrocodone, hydromorphone) will not react with this test.

Concentrations of drugs and/or metabolite(s) detected in urine have not been correlated to drug levels in the bloodstream or with the degree of impairment. The presence of a drug and/or metabolite(s) in urine is only an indication of previous drug exposure.

Clinical Utility

Oxycodone is a semi-synthetic narcotic analgesic generally prescribed for the relief of moderate to severe pain. Its potency is approximately equivalent to morphine. Oxycodone is available as a single compound, but is often combined with other analgesics like acetaminophen or aspirin. Oxycodone has a high potential for physical and psychological dependence.

CPT Codes

80307, 80365 (alternate: G0479, G0480).
LOINC: 60276-3, 13576-4, 3893-5, Codeine 16197-6, Morphine 16196-8, Hydrocodone 19483-7, Hydromorphone 18473-9, Oxycodone 19643-6, Oxymorphone 18325-1


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