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Lupus Anticoagulant

Department

Coagulation

Instructions

Lupus Anticoagulant, per se, is not an orderable test. Due to the complexity of testing for antiphospholipid antibodies, orders for "Lupus Anticoagulant" are reflexed to the following: Coagulation Consultation for Pathology, Antiphospholipid Antibodies.

The consultation offers an interpretation along with the necessary number of tests to diagnose or exclude Lupus Anticoagulant. Alternatively, individual tests for Lupus Anticoagulant (e.g. Inhibitor/Anticoagulant Screen, Dilute Russell Viper Venom Test (dRVVT), and/or Hexagonal Phase Phospholipid) can be ordered without interpretation. For specific information, refer to the tests individually in the Lab Test Directory.

OF NOTE: The International Society on Thrombosis and Hemostasis (ISTH) recommends that at least two different lupus anticoagulant sensitive tests (i.e. two of the three tests listed above) be normal before excluding the presence of a lupus anticoagulant. Furthermore, if one of these tests is positive, it should be repeated in twelve weeks to exclude a transient, clinically insignificant antibody. Diagnosis of antiphospholipid syndrome (ISTH criteria) requires laboratory evidence of an antiphospholipid antibody (anticardiolipin or beta-2 glycoprotein I of sufficient titer, or lupus anticoagulant) on two occasions at least twelve weeks apart.

Contacts

Last Updated

4/8/2024