Liver / Kidney Microsome Type 1 Antibody, IgG
P450 2D6 Antibody
Test Codes
EPIC: LAB6086, Beaker: XLKM, Warde: LKMAB
Department
Send Outs
Specimen Collection Criteria
Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.
Physician Office/Draw Specimen Preparation
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)
Rejection Criteria
- Lipemic specimens.
- Grossly hemolyzed specimens.
- Heat-treated Specimens.
- Microbally contaminated specimens.
- Plasma
- Specimens not collected and processed as indicated.
In-Lab Processing
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 21 days
Frozen (-20°C/-4°F or below): Undetermined
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.
Laboratory
Sent to Warde Medical Laboratory, Ann Arbor, MI.
Performed
Monday – Friday.
Results available in 2-5 days.
Reference Range
Negative: Less than or equal to 20.0 Units.
Equivocal: 20.1 - 24.9 Units.
Positive: Greater than or equal to 25.0 Units.
Test Methodology
Enzyme Immunoassay (EIA).
Interpretation
LKM (liver kidney microsome) autoantibodies are found in a subgroup of patients with ANA-negative autoimmune chronic active hepatitis. Antibody to hepatitis C virus can be found in about 50% of patients with low LKM autoantibody titers.
Antibodies to liver kidney microsome antigens (anti-LKM1) occur in a subset of patients with chronic autoimmune hepatitis. These patients have a high frequency of associated immunologic disorders and an absence of non-organ specific autoantibodies (smooth muscle antibodies). Most patients with type of chronic autoimmune hepatitis are children.
Clinical Utility
This assay is used to detect a clinically specific antibody in patients with autoimmune chronic hepatitis (type 2).
CPT Codes
86376
Contacts
Send Outs Laboratory – RO
248-551-9045
Name: Send Outs Laboratory – RO
Location:
Phone: 248-551-9045
Last Updated
4/23/2024
Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.