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Insulin Like Growth Factor Binding Protein 3

IGF Binding Protein 3, IGFBP3

Test Codes

EPIC: LAB7118, SOFT: IGFP3

Department

Special Chemistry

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within eight hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

Lipemic or icteric specimens.

Grossly hemolyzed specimens.

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of eight hours. (Minimum Serum: 0.5 mL)

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Monday – Friday.
Results available within 2 business days.

Reference Range

Age	Male (ng/mL)	Female (ng/mL)
0-12 months 1-3 years 4-5 years 6-7 years 8-9 years 10-11 years 12-13 years 14-15 years 16-17 years 18-19 years 20-24 years 25-29 years 30-34 years 35-39 years 40-44 years 45-49 years 50-54 years 55-59 years 60-64 years 65 years and older	1039-3169 972-4123   1843-4968 1838-4968 1932-5858 1828-6592 2134-6598 2330-6550 2380-6400 2340-6632 2404-5948 2614-5792 2500-5806 2474-5208 2360-5560 2314-5700 2528-5050 2482-5460 2592-4770 2698-5688	1039-3169 1590-4225 2169-4790 2188-4996 2072-5504 2456-6992 2838-6846 2654-6680 2756-6908 2700-6492 3032-5992 2926-5858 2878-6650 2786-6084 2514-6014 2838-4954 2562-5596 2574-5914 2684-5130 2462-5274
Tanner Stage I Tanner Stage II Tanner Stage III Tanner Stage IV & V	1878-6190 2112-6208 2372-6602 2336-6414	2314-6086 2732-6738 2870-7068 2756-7232

Test Methodology

Chemiluminescent Immunoassay

Clinical Utility

Insulin-like growth factors 1 and 2 (IGF-1, IGF-2) are small polypeptides involved in the regulation of cell growth. IGF-1 and IGF-2 are bound to insulin-like growth factor binding proteins, six of which have been described. IGFBP-3 is the predominant of these, binding ~95% of circulating IGF-1 and IGF-2. 

IGF-1 serves as the major mediator of the anabolic and growth-promoting effects of growth hormone. Secretion patterns of IGF-1 and IGFBP-3 mirror each other, and are primarily growth hormone dependent. In contrast to growth hormone production, which is pulsatile and demonstrates significant diurnal variation, IGF-1 and IGFBP-3 levels exhibit only minor fluctuations. Given that, serum measurements of IGF-1 and IGFBP-3 represent a more stable assessment of growth hormone production, and aid in the evaluation of growth disorders and growth hormone deficiency.

CPT Codes

82397
LOINC: 2483-6

Contacts

Last Updated

1/11/2023