Lab Test

Immunoglobulin G (IgG)

IgG, Immunoglobulin G, Serum

Test Codes

Antrim #30435, EPIC: LAB5786, SOFT: IGG

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 4.0 mL)

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within 12 hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

  • Grossly lipemic specimens.
  • Hemolyzed specimens.
  • Plasma specimens.

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of 12 hours. (Minimum Serum: 0.5 mL)

For more information on this test please see procedures at 

Storage

Specimen Stability for Testing:

Centrifuged SST tubes, Red-top tubes, and Microtainers®
Room Temperature (20-26°C or 68-78.8°F): 12 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 12 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Automated Chemistry Laboratory

Performed

Sunday – Saturday.
Results available within 24 hours of receipt in the Laboratory.

Reference Range

(mg/dL)   
 0-14 Days 320-1400 
 15 Days - 11 months  320-1150
 1-3 Years  540-1360
 4-9 Years  660-1530
 10-18 Years  550-1650
 Adult  

Methodology: Immunoturbidimetric

Test Methodology

Nephelometry.

Interpretation

Decreased levels of IgG are associated with selective hypo-IgG, protein losing enteropathies, pregnancy, and nephrotic syndrome.

Increased IgG levels are associated with infectious diseases (hepatitis, rubella, infectious mononucleosis), parasitic diseases, rheumatoid arthritis, systemic lupus erythematosus, polyclonal and monoclonal gammopathies, multiple myeloma, monocytic leukemia, and Hodgkin's disease.

Half Life in Blood: 21 days.

Clinical Utility

IgG levels can be used to evaluate humoral immunity and aids in the diagnosis of conditions associated with IgG excess or depression. IgG can cross the placenta. IgG antibodies are the most important and persistent antibodies of the secondary immune response.

CPT Codes

82784

Contacts

Last Updated

4/23/2020

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

 

This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.