Lab Test

IA-2 Antibody

Insulin Antibodies, Islet-cell Antibodies, GAD65 Antibody, Zinc Transporter 8 Antibody, Diabetes Autoimmune Test Group

Test Codes

EPIC: LAB1232322, Beaker: IA-21, Quest: 37933

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube. 

Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Rejection Criteria

  • Grossly hemolysis.
  • Lipemic specimen.
  • Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Transport: 1.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Tuesday, Thursday, Saturday.
Results are available in 3-5 days.

Reference Range

<5.4 U

Test Methodology

Enzyme Linked Immunosorbent Assay (ELISA)

Clinical Utility

IA-2 Antibody – Type 1 Diabetes Mellitus is characterized by lymphocytic cell infiltration of the beta-cells of pancreatic islets. Measurement of IA-2, GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type I diabetes.

CPT Codes

86341

Contacts

Last Updated

4/15/2026

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