Lab Test

Hypoglycemic Agent Screen

Sulfonylureas Panel (chlorpropamide, tolazamide, tolbutamide, acetohexamide, glipizide, glyburide, glimepiride), Meglitinides (repaglinide)

Test Codes

MAYO: HYPOG, EPIC: LAB6279, Beaker: XHYPG

Department

Send Outs

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes and centrifuge to separate serum from cells. Transport serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 3.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 1.1 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Grossly icteric specimens.
  • Grossly lipemic specimens.
  • Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes and centrifuge to separate serum from cells. Transport serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Transport: 3.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 1.1 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday, Wednesday, Friday.
Results available in 3-9 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Clinical Utility

The metabolic and hormonal profiles of insulinoma and sulfonylurea-induced hypoglycemia are identical. Therefore, in the evaluation of the hypoglycemic patient, the possible use of oral hypoglycemic agents as the cause for low blood glucose and elevated plasma insulin must be considered. Absence of hypoglycemic drugs in blood serum during an episode of low blood glucose should be demonstrated before considering pancreatic exploration for suspected insulinoma.

CPT Codes

80377

Contacts

Last Updated

11/18/2021

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