Histone Antibody, IgG

Anti-Histone Antibody, AHA

Test Codes

EPIC: LAB1231927, Beaker: Histone Ab, Quest: 37056

Department

Send Outs

Instructions

Overnight fasting preferred.

Specimen Collection Criteria

Collect: One Gold-top SST tube.
Also Acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8 °C or 36-46 °F). (Minimum: 0.3 mL)

Rejection Criteria

Specimen not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and maintain at refrigerate (2-8°C or 36-46) prior to transport.

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.3 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 30 days

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Wednesday, Friday.
Results available within 3-6 days.

Reference Range

Value            Explanation of Results
<1.0               Negative
1.0-1.5           Weak Positive
1.6-2.5           Moderate Positive
>2.5               Strong Positive

Test Methodology

Enzyme Immunoassay (EIA)

Clinical Utility

Histone Antibodies – Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.

CPT Codes

83516
LOINC: 43231

Contacts

Last Updated

11/19/2025