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Fibrin Degradation Products

FSP, FDP, Fibrin Breakdown products, Fibrin Split Products

Test Codes

Temporary code: XMISC LAB6433 – Ask order question: free text “FDP”
Fibrin Split Products EPIC: LAB7610

Department

Send Outs

Instructions

Specimens with hematocrit values greater than 55% must have anticoagulant adjusted. Specimens must be re-collected using a specified whole blood to sodium citrate ratio. Contact the performing Laboratory for specific instructions.

Specimen Collection Criteria

Collect: One Light Blue-top B3.2% Sodium Citrate tube OR One Pediatric Light Blue-top Sodium Citrate tube (1.8 mL)

TUBE MUST BE FULL. 

Physician Office/Draw Specimen Preparation

For optimal results, maintain whole blood specimen at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport whole blood to the Laboratory within 1 hour of collection. If transport within 1 hour is not possible, the following procedure must be followed for accurate results:

1. Centrifuge the capped tubes at 1500 x g for 15 minutes.
2. Transfer plasma with plastic pipette into a plastic polypropylene centrifuge tube, cap and centrifuge an additional 15 minutes at 1500 x g to obtain platelet poor plasma (PPP) which has a platelet count less than 10.0 bil/L. Plasma with a platelet count of less than 10.0 bil/L is critical for accurate results.
3. Immediately remove only the top two-thirds of the PPP and transfer into a screw cap, 5.0 ml, 75 x 13 mm, round base, polypropylene tube.  
4. Freeze (-20°C/-4°F or below) the PPP immediately.
5. Transport frozen on DRY ICE. Specimen must remain frozen during transport. 

Preparation for Courier Transport

Transport: Whole blood at room temperature (20-25°C or 68-77°F), or plasma obtained through the process listed above, frozen (-20°C/-4°F or below). 

Rejection Criteria

• Glass tubes and 3.8% Sodium Citrate tubes.
• Specimens that are clotted or grossly hemolyzed.
• Inappropriate specimen volume.
• Thawed or partially thawed specimens.

In-Lab Processing

Whole blood specimens must be processed as follows upon receipt in the Laboratory: 

1. Centrifuge the capped tubes at 1500 x g for 15 minutes.
2. Transfer plasma with plastic pipette into a plastic polypropylene centrifuge tube, cap and centrifuge an additional 15 minutes at 1500 x g to obtain platelet poor plasma (PPP) which has a platelet count less than 10.0 bil/L. Plasma with a platelet count of less than 10.0 bil/L is critical for accurate results.
3. Immediately remove only the top two-thirds of the PPP and transfer into a plastic tube.
4. Test or freeze specimen according to lab protocol.

Storage

Specimen Stability for Testing:

Whole Blood
Room Temperature (20-26°C or 68-78.8°F): 1 hour
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Platelet Poor Plasma (PPP)
Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 30 days

Laboratory

Royal Oak Send Outs Laboratory
Corewell Health Reference Laboratory, Grand Rapids, MI 

Performed

Sunday – Saturday, 24 hours a day.
Results available within 24-48 hours.

Reference Range

Normal Value: Less than 5.0 mcg/mL.

Test Methodology

Rapid latex slide agglutination test using mouse anti-FDP antibodies.

Interpretation

• Fibrin split products are elevated in DIC.
• This test is not specific for Fragments D and E but will also react with fibrinogen, FSP (X, Y, D and E) and fibrin monomer.

Clinical Utility

• Fibrin(ogen) split products are formed by digestion of fibrin(ogen) as a result of activation of the fibrinolytic system.
• This test aids in the detection of DIC.
• This test is not to be used for the exclusion of deep vein thrombosis (DVT) or pulmonary embolism (PE).

CPT Codes

85362

Contacts

Last Updated

8/12/2025