Estrone

Estrone, Serum

Test Codes

EPIC: LAB1232008, Beaker: ESTRONE, Quest: 23244

Department

Send Outs

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes (SST).

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.25 mL)

Rejection Criteria

• Gross hemolysis.
• Specimens not collected and processed as indicated.
• Specimens collected in SST tubes.
• Lipemia.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.25 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 30 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Daily.
Results are available in 2-4 days.

Reference Range

Adult
Male	≤68 pg/mL
Female
Follicular Phase	10-138 pg/mL
Luteal Phase	16-173 pg/mL
Postmenopausal Phase	≤65 pg/mL

Pediatric

Age	Male (pg/mL)	Female (pg/mL)
Pre-pubertal (1-9 years)	<10	≤34
10-11 years	≤12	≤72
12-14 years	≤28	≤75
15-17 years	≤64	≤188

Test Methodology

Chromatography / Mass Spectrometry

Interpretation

By report.

Clinical Utility

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women.

CPT Codes

82679

Contacts

Last Updated

12/17/2025