Desmoglein Antibodies (1 and 3)

DSG1, DSG3, Bullous Pemphigus, Desmoglein 1 (DSG1) and Desmoglein 3 (DSG3), IgG Antibodies, Serum, Pemphigus Foliaceus, Pemphigus Vulgaris

Test Codes

EPIC: LAB1232199, Beaker: DSG1&DSG3, Quest: 16033

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.

Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 0.5 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 0.3 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Wednesday, Friday.
Results available in 3-7 days.

Reference Range

Desmoglein 1 Antibody	<20 RU/mL
Desmoglein 3 Antibody	<20 RU/mL

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Clinical Utility

Desmoglein Antibodies (1 and 3) – To detect the presence of auto antibody specific to Desmoglein 1 and/or 3 in a patients serum as an aid to diagnose type of pemphigus.

CPT Codes

83520 x2

Contacts

Last Updated

12/17/2025