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D Lactate, Plasma

D-Lactate, Plasma

Test Codes

MAYO: DLAC, EPIC: LAB6249, SOFT: XLACP

Department

Send Outs

Specimen Collection Criteria

Collect: One Grey-top Potassium Oxalate/Sodium Fluoride tube.

Physician Office/Draw Specimen Preparation

Centrifuge to separate plasma from cells. Transport plasma to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 1.0 mL plasma, frozen (-20°C/-4°F or below). (Minimum: 0.55 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate plasma from cells. Transport plasma to a plastic transport tube and freeze (-20°C/-4°F or below).

Transport: 1.0 mL plasma, frozen (-20°C/-4°F or below). (Minimum: 0.55 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Varies.
Results available in 5-9 days.

Reference Range

By report.

Test Methodology

Enzymatic.

Interpretation

D-lactate is a product of bacterial overgrowth in the gastrointestinal tract. It should not be confused with L-lactate which accumulates in some metabolic acidosies.

D-lactate is readily cleared. Urine is the preferred sample.

Elevated levels of D-lactate are often seen in patients with the short-bowel syndrome and following jejunoileal bypass when D-lactate is present.

Clinical Utility

D-lactate is produced by colonic bacteria from carbohydrates not absorbed in the small intestine. When large amounts are not absorbed it can cause metabolic acidosis, altered mental status and a variety of neurologic symptoms.

D-lactic acidosis is typically observed with patients with short-bowel syndrome and following jejunoileal bypass resulting in carbohydrate malabsorption.

CPT Codes

83605
LOINC:  14045-9

Contacts

Last Updated

7/6/2021