Lab Test

Cytogenetics Leukemic Blood (Oncologic) Karyotype

Karyotyping, Chromosome Analysis, Karyogram, blood karyotype, genetic, GBLOG, cytogenetics, leukemic blood, oncologic blood

Test Codes




Specimen Collection Criteria

Collect: 6.0 mL whole blood in Dark Green-top Sodium Heparin tubes. (Minimum: 1.0 mL)

  • Gently invert the tube to mix the specimen.
  • A copy of the requisition must be sent with the specimen. The requisition form should contain the patient name, birth date, medical record number, requesting physician, specimen type and test requested, date and time of collection, and tentative diagnosis.

Physician Office/Draw Specimen Preparation

Do not freeze specimen. Maintain specimens at room temperature (20-25°C or 68-77°F) prior to courier pickup. For delays in transport (greater than 24 from the time of collection), refrigerate (2-8°C or 36-46°F) the specimen.

Preparation for Courier Transport

Transport: 6.0 mL whole blood in Dark Green-top Sodium Heparin tubes, at room temperature (20-26°C or 68-78.8°F) or refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

Specimens arriving in the laboratory 4 days or more following the original collection date. 

Clotted and suboptimal specimens (volume less than 1.0 mL) will be cultured but the Laboratory cannot guarantee a final result.

In-Lab Processing

Specimens are processed immediately upon receipt in the Laboratory.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 96 hours
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days. A backup cell pellet is maintained for three weeks past sign-out of the final report.


Royal Oak Cytogenetics Laboratory


Monday – Friday, 8:00 am – 5:00 pm.
Results available within 7-14 days of receipt in the Laboratory.
STAT preliminary results available within 48 hours of receipt of the specimen, and a final result will be available within 7 days.

Reference Range

Normal results would be 46,XX or 46,XY with no apparent abnormalities present.

Test Methodology

High-resolution microscopic analysis of chromosomes to provide a digital image karyotype. Special stains or techniques such as C-Banding, NOR Banding and FISH may be required to further identify specific chromosomal abnormalities or variants. 


Based on completion of chromosomal analysis. Interpretation will be issued in the form of a final report.

CPT Codes

88237, 88262, 88280.


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