Lab Test

CYP2C19 Genotyping

CYP2C19 Genotyping for Clopidogrel/Plavix, Clopidogrel (Plavix), Cytochrome P450 2C19 Genotyping, Plavix (Clopidogrel), Treatment Resistant Depression Panel, Plavix Inhibition

Test Codes

ARUP #3001508, EPIC: LAB7036, SOFT: XYP19


Send Outs

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube. (Minimum: 1.0 mL)
Also acceptable: One Yellow-top ACD tube. 

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood refrigerated (2-8°C or 36-46°F). Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

This test will only be performed once in a lifetime for a patient.


Specimen Stability for Testing:

Whole Blood
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 1 week
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Extracted DNA may be available for additional testing if clinically indicated.

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Results available in 6-11 business days.

Reference Range

By Report.

Test Methodology

Polymerase Chain Reaction (PCR)/ Fluorescence.


This test detects by report (normal) allele CYP2C19*1, and the following mutant alleles: *2 → *10, *13, and *17.

Clinical Utility

  • Based on the CYP2C19 genotype, patients may be classified as extensive, intermediate, poor, or ultrarapid metabolizers of Clopidogrel. Drug dose selection based on genotype is the basis of individualized therapy.
  • Testing is recommended on patients to be started on Plavix (Clopidogrel) therapy.

CPT Codes

LOINC:  31208-2, 57132-3, 50398-7


Last Updated


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