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Cryopreservation

Chromosome Testing, Cryopreservation, Cryogenics, genetic, GCRYG

Test Codes

EPIC: LAB6465

Department

Cytogenetics

Specimen Collection Criteria

Any specimen obtained for Cytogenetic studies may additionally be cryopreserved for future studies and send out testing. Specimens may include but are not limited to: Tissues, Amniotic Fluids, Chorionic Villus Biopsies, Products of Conception, Peripheral Bloods, Bone Marrows, Solid Tumors or Lymph Nodes. Please refer to the specific test page in the Lab Test Directory for collection protocols. 

Physician Office/Draw Specimen Preparation

All specimens should be transported to the Laboratory as soon as possible for processing. Please refer to the specific test page in the Lab Test Directory for storage protocols. 

Preparation for Courier Transport

Most specimens can be transported at room temperature (20-26°C or 68-78.8°F) for a minimum of 24 hours, or transported refrigerated (2-8°C or 36-46°F). Avoid temperature extremes and refer to the specific test page in the Lab Test Directory for transportation protocols. 

Rejection Criteria

• Specimens arriving in the laboratory 4 days or more following the original collection date.
• Fixed or frozen specimens.
• Specimens arriving contaminated or suboptimal in size or condition (refer to the specific test page in the Lab Test Directory for size/volume requirements). 

In-Lab Processing

Specimens are processed according to their specific protocol immediately upon delivery to the Cytogenetics Laboratory. 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 96 hours
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

No time limit. 

Laboratory

Royal Oak Cytogenetics Laboratory

Performed

Monday – Friday, 6:00 am – 5:30 pm.
Tissues that are cryopreserved may be reinitiated at the request of a physician and utilized for additional studies or send out testing. 

Test Methodology

Cryopreservation allows specimens to be cryogenically stored in liquid nitrogen tanks for an indefinite period of time. The cell suspensions are exposed to DMSO and then frozen and stored in liquid nitrogen tanks. Cells may be reinitiated at a later date at the request of a physician and utilized for additional studies and send out testing. 

Clinical Utility

Cryopreservation of specimens allows physicians to cryogenically store a patient specimen for an indefinite time period. Cells may be reinitiated at the request of a physician to allow for biochemical, metabolic, molecular, and other specialized send out testing of patient specimens. 

CPT Codes

88233, 88240. 

Contacts

Last Updated

12/30/2022