Lab Test


Cryofibrinogen, Plasma

Test Codes

Antrim #15502, EPIC: LAB5827, SOFT: CRYOP


Special Chemistry


  • Blood must ONLY be collected at the Grosse Pointe, Royal Oak, or Troy hospitals campuses. It should NOT be collected at any other Beaumont Lab draw site.
  • Blood must only be collected Monday – Friday, 6:00 am – 3:00 pm.
  • Ideally patients should be fasting for 9-12 hours prior to blood collection, however this is not absolutely essential and non-fasting samples will be accepted. 

Specimen Collection Criteria

Collect: Two Lavender-top EDTA tubes and one plain Red-top tube, pre-warmed and transported at 37°C.

If Cryoglobulin testing is ordered with Cyrofibrinogen, the Red-top tube does not need to be drawn for the Cyrofibrinogen.

Rejection Criteria

Samples not kept at 37°C from the time of collection to receipt in the Laboratory. 

Severely hemolyzed, lipemic or icteric specimens. 


Inpatient Specimen Preparation

Royal Oak

  • Blood must only be collected Monday – Friday, 6:00 am – 3:00 pm.
  • Samples will only be accepted when obtained in the Royal Oak Hospital, the MOB, Imaging Center, or Cancer Center Labs.
  • Blood collection tubes must be placed into a thermos bottle with a warm pack at 
    37°C. The thermos should be obtained from Special Testing (extension 18044).
  • Specimen must be delivered through the pneumatic tube system in a thermos bottle with warm pack at 37°C.


  • After the specimen is drawn it should be immediately placed in a 37°C dry heating block and immediately transported to the Laboratory.

Grosse Pointe

  • Five minutes before drawing the blood, break the seal on the infant heel warmer, wrap it around a Red-top tube/vacutanier, and place into an orange capped container to warm.
  • After blood collection, break the seal on a second infant heel warmer, and place the new infant warmer into the container.
  • After the specimen is delivered to the Laboratory it should be immediately placed in a 37°C water bath. 


Royal Oak Special Chemistry Laboratory
Troy Chemistry Laboratory


Collected: Monday – Friday, 6:00 am – 3:00 pm.
Results available in 7 days.

Reference Range


Test Methodology



Lipemia interferes with assay.

Heparin should not be used as an anticoagulant in this assay. Small amounts of cold precipitable protein are frequently observed in the plasma of normal subjects and in the plasma of patients with an acute febrile illness when heparin is used.

Clinical Utility

Cryofibrinogenemia in excess of 100 mg/dL of plasma may be associated with sensitivity to cold, Raynaud's syndrome, ischemic cutaneous lesions, purpura, epistaxis, and a tendency to thrombosis. It has also been observed in patients with metastatic malignant disease, particularly in metastatic carcinoma of the prostate and occasionally in patients with other diseases such as leukemia, lymphoma, collagen disease, and primary thromboembolic disease. Primary idiopathic cryofibrinogenemia has also been described.

CPT Codes

LOINC: 46265-5


Last Updated


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