Coxsackie A Antibodies

Coxsackie A9 Virus Antibodies by CF, Coxsackie A Virus Antibodies, Hand, foot and mouth disease

Test Codes

EPIC: LAB757, Beaker: Coxsackie A, Quest: 37477

Department

Send Outs

Instructions

Testing includes: Coxsackie Antibodies A2, A4, A7, A9, A10, A16

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 2.0 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and maintain at room temperature (20-26°C or 68-78.8°F).

Transport: 2.0 mL serum, room temperature (20-26°C or 68-78.8°F). (Minimum: 1.0 mL) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Monday – Friday.
Results available in 3-5 days.

Reference Range

Coxsackie A2 Ab	<1:8 titer
Coxsackie A4 Ab	<1:8 titer
Coxsackie A7 Ab	<1:8 titer
Coxsackie A9 Ab	<1:8 titer
Coxsackie A10 Ab	<1:8 titer
Coxsackie A16 Ab	<1:8 titer

Interpretive Criteria

<1:8	Antibody Not Detected
≥1:8	Antibody Detected

Test Methodology

Complement Fixation (CF)

Clinical Utility

Coxsackie A Antibodies, Serum – Panel currently includes testing against A-2, 4, 7, 9, 10, and 16 antigens. Although there is cross-reactivity among the enteroviruses by CF, most healthy people do not have titers >1:8. Therefore, detectable titers, especially those >1:32, should be considered diagnostic. Confirmed serodiagnosis is made by demonstration of a four-fold change in titers between acute and convalescent sera.

Contacts

Last Updated

11/19/2025