Mayo: COS, EPIC: LAB5981, Beaker: XCO
High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Specimen Collection Criteria
Collect (preferred specimen): One Royal Blue-top tube with no additive.
Physician Office/Draw Specimen Preparation
Centrifuge to separate serum from cells. Transfer serum a metal free transport tube within two hours of collection and maintain specimen at room temperature (20-26°C or 68-78.8°F) prior to transport.
Preparation for Courier Transport
Transport: 2.0 mL serum or plasma, at room temperature (20-25°C or 68-77°F). (Minimum: 0.5 mL)
Tubes that are not metal-free.
Specimens not collected and processed as indicated.
Centrifuge to separate serum from cells. Transfer serum to a metal free transport tube within two hours of collection and maintain specimen at room temperature (20-26°C or 68-78.8°F) prior to transport.
Transport: 2.0 mL serum, at room temperature (20-26°C or 68-78.8°F). (Minimum: 0.5 mL)
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 28 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.
Sent to Mayo Clinic Laboratories in Rochester, MN.
Results available in 2-6 days.
Quantitative Inductively Coupled Plasma/Mass Spectrometry.
Serum cobalt levels can be used in the assessment of occupational exposure or toxic ingestion and is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum cobalt levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Symptoms associated with cobalt toxicity vary based on route of exposure, and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.
Serum or plasma cobalt testing is intended to detect potentially toxic exposure.
Send Outs Laboratory – RO
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