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Chloride, Urine

Urine Chloride

Test Codes

24 Hour Urine: EPIC: LAB541, Beaker: CLU24, Random Urine: EPIC: LAB5440, Beaker: CLU

Department

Chemistry

Instructions

Note: 24-hour and random urine specimens MUST be collected separately. See below for collection criteria.

• Please refer to the Specimen Collection Manual for instructions on 24-Hour or Random Urine Collection:
  • Urine 24-Hour Collection – Inpatient.
  • Urine 24-Hour Collection – Outpatient.
  • Urine 24-Hour Collection – Outreach.
  • Random Urine Collection

Specimen Collection Criteria

Collect: 24-hour urine or timed urine specimen with a 24-hour urine container with no preservatives.
Also acceptable: Random urine specimen in a screw-capped container (preferred) or another sterile collection cup. Preservatives are not acceptable for random urine specimens. (Minimum: 20 mL)

• Refer to the table of Urine Preservative Options when multiple tests are requested.
• Keep 24-hour urine specimen iced or refrigerated during collection.
• Include start and end dates and times for the collection period on the specimen container.

Urine Preservative Options
No Preservative	6N Hydrochloric Acid	Boric Acid (10g)	Sodium Carbonate	50% Acetic Acid
Preferred	Unacceptable	Acceptable	Unacceptable	Unacceptable

Physician Office/Draw Specimen Preparation

Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Entire 24-hour urine collection, or random urine, refrigerated (2-8°C or 36-46°F).

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Measure total volume of 24-hour urine specimen. Record total volume and collection start and end dates and times in the LIS system. Aliquot a minimum of 10 mL from the well-mixed 24-hour urine collection.

Storage

Specimen Stability for Testing:

Room temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): For longer storage.

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days (Royal Oak and Troy store an aliquot for 30 days.)

Laboratory

Dearborn, Chemistry Laboratory
Farmington Hills Chemistry Laboratory

Grosse Pointe Chemistry Laboratory
Royal Oak Automated Chemistry Laboratory
Troy Chemistry Laboratory

Performed

Sunday – Saturday.
Results available within 24 hours. 

Reference Range

Urine Chloride: 110-250 mmol/24 hours.
Normal ranges for random urines or for collections other than 24 hours have not been established.

Test Methodology

Potentiometry.

Interpretation

Urinary chloride levels less than 10 mmol/L are seen in chloride responsive disorders such as diuretic therapy, GI causes, rapid correction of hypercapnia, carbenicillin administration and reduced dietary intake. Levels greater than 20 mmol/L are seen in chloride unresponsive disorders such as hyperaldosteronism or Cushing's syndrome, exogenous steroid use, Bartter's syndrome, or alkali ingestion.

Clinical Utility

Urinary chloride measurements aid in the differentiation of causes of metabolic alkalosis and help classify them as chloride responsive or unresponsive.

CPT Codes

82436

Contacts

Last Updated

10/30/2023