Lab Test


Calpro, Fecal Calprotectin, Stool Calprotectin

Test Codes



Special Chemistry

Specimen Collection Criteria

Collect: Random stool sample in a sterile collection cup without preservative or additives. (Minimum: 1.0 g)

Physician Office/Draw Specimen Preparation

After collection and prior to transport, store collection cup containing stool specimen refrigerated (2-8°C or 36-46°F). 

Preparation for Courier Transport

Transport: Stool specimen, refrigerated (2-8°C or 36-46°F). (Minimum 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

Specimens collected from a diaper.

In-Lab Processing

Store specimens for up to 10 days refrigerated (2-8°C or 36-46°F). If stool samples will not be tested within 10 days, store frozen (-20°C/-4°F or below). 


Random Stool
Room Temperature (20-26°C or 68-78.8°F): 18 hours
Refrigerated (2-8°C or 36-46°F): 10 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days


Royal Oak Special Testing Laboratory


Monday, Wednesday, Friday.
Results available in approximately 3-5 business days.

Reference Range

Calprotectin Interpretation Clinical Recommendation
Less than or equal to 50 mcg/g
Normal Monitor patient clinically. Endoscopy may not be necessary, particularly in the pediatric population.
51 - 120 mcg/g
Borderline Repeat test in 4 - 6 weeks or perform additional studies to exclude/confirm IBD
Greater than or equal to 121 mcg/g
Abnormal Supports the diagnosis of IBD. Further testing to determine the etiology of the GI inflammation is indicated.

Test Methodology

Quantitative Enzyme-linked Immunosorbent Assay (ELISA).

Clinical Utility

Calprotectin can be used to aid in the diagnosis of Inflammatory Bowel Diseases (IBD), and to differentiate IBD from Irritable Bowel Syndrome (IBS) in conjunction with other clinical and laboratory findings.

CPT Codes

LOINC: 38445-3


Last Updated


Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.