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BCR/ABL1 Tyrosine Kinase Inhibitor Resistance

T315I
CAUTION: This test is not same test as Muscle-Specific Kinase (MuSK) Antibody, IgG.

Test Codes

EPIC: LAB7586, Beaker: XBCRTKR, Mayo: BAKDM

Department

Send Outs

Instructions

Note: BCR/ABL fusion type must be provided for testing to be performed (p210, p190, p205, p230).

Specimen Collection Criteria

Collect: Whole blood or bone marrow in Lavender-top EDTA tubes.

Physician Office/Draw Specimen Preparation

Do not centrifuge or freeze. Maintain specimens in original tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 8 mL whole blood or 4 mL bone marrow, refrigerated (2-8°C or 36-46°F). (minimum whole blood 4 mL; minimum bone marrow 2 mL)

Rejection Criteria

Clotted.

Specimens not collected and processed as indicated.

In-Lab Processing

Do not centrifuge or freeze. Maintain specimens in original tube and refrigerate (2-8°C or 36-46°F).

Transport: 8mL whole blood or 4mL bone marrow, refrigerated (2-8°C or 36-46°F). (minimum whole blood 4 mL; minimum bone marrow 2 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 5 days
Frozen (-20°C/-4°F or below): unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday – Friday.
Results available in 6-8 days.

Reference Range

By report.

Test Methodology

Reverse Transcription – Polymerase Chain Reaction (RT-PCR) and DNA Sequencing.

Interpretation

By report.

Clinical Utility

CPT Codes

81170

Contacts

Last Updated

8/24/2023