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Angiotensin Converting Enzyme, CSF

ACE-CSF, Angiotensin Converting Enzyme, CSF

Test Codes

EPIC: LAB6610, Beaker: XACE, ARUP: 98974

Department

Send Outs

Specimen Collection Criteria

Collect: 1.0 mL Cerebrospinal Fluid (CSF) in a sterile collection container. (Minimum: 0.3 mL)

Send specimen for processing immediately after collection.

Physician Office/Draw Specimen Preparation

Maintain specimen frozen (-20°C/-4°F or below) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL CSF, frozen (-20°C/-4°F or below). (Minimum: 0.5 mL)

Rejection Criteria

• Hemolyzed specimens.
• Xanthochromic specimens.
• CSF containing gadolinium – based contrast agents.
• Specimens not collected and processed as indicated.

In-Lab Processing

Maintain specimen frozen (-20°C/-4°F or below) prior to transport.

Transport: 1.0 mL CSF, frozen (-20°C/-4°F or below). (Minimum: 0.5 mL) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday, Wednesday, Friday.
Results available in 1–5 days.

Reference Range

0-2.5 U/L.

Test Methodology

Quantitative Spectrophotometry.

Clinical Utility

CSF Angiotensin Converting Enzyme (ACE) levels may help support the diagnosis of neurosarcoidosis; however, this test is not specific for neurosarcoidosis. In neurosarcoidosis, serum ACE concentrations are less likely than CSF ACE concentrations to be elevated. CSF ACE levels are increased in about 55% of patients with neurosarcoidosis, 5% of those with sarcoidosis (without neurologic abnormality) and 13% of those with other neurological diseases. Levels can be used to evaluate response to treatment.

CPT Codes

82164

Contacts

Last Updated

10/17/2023