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Aminolevulinic Acid Dehydratase, Erythrocytes

Porphobilinogen Synthase, PBG Sunthetase, ALA-D, ALAD, AIP

Test Codes

EPIC: LAB6222, Beaker: XALAE, Mayo: ALAD

Department

Send Outs

Instructions

• Patient should abstain from alcohol for 24 hours prior to specimen collection.
• Include a list of medications the patient is currently taking and forward with the specimen.

Specimen Collection Criteria

Collect (preferred specimen): One Dark Green-top Sodium Heparin tube. (Minimum: 3.0 mL)
Also acceptable: One Dark Green-top Lithium Heparin or Lavender-top EDTA tube.

• Collect and transport specimen on ice.
• Send specimens for processing immediately after collection.

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood specimen refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood, refrigerated (2-8°C or 36-46°F) or on wet ice. (Minimum: 3.0 mL)

Rejection Criteria

• Hemolyzed specimens.
• Specimens not collected and processed as indicated.

Inpatient Specimen Preparation

Deliver specimen to the Laboratory, on ice, immediately after collection.

In-Lab Processing

Do not centrifuge. Maintain whole blood specimen refrigerated (2-8°C or 36-46°F) prior to transport. The specimen must be received at Mayo Medical Laboratories within 48 hours of collection.

Transport: Whole blood, refrigerated (2-8°C or 36-46°F) or on wet ice. (Minimum: 3.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories, Rochester, MN.

Performed

Tuesday and Thursday.
Results available in 2-4 days.

Reference Range

By report. Reference range has not been established for patients under 16 years of age.

Test Methodology

Enzymatic End-Point / Spectrofluorometric.

Interpretation

By report.

Clinical Utility

Confirmation of a diagnosis of dehydratase aminolevulinic acid deficiency porphyria (ADP).

CPT Codes

82657

Contacts

Last Updated

10/16/2023