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Alpha 1 Antitrypsin, Random Stool

Alpha-1-Antitrypsin

Test Codes

EPIC: LAB558, Beaker: A1A stool, MAYO: A1AF

Department

Send Outs

Specimen Collection Criteria

Collect: 5.0 grams random stool specimen in a sterile collection container. (Minimum: 1.0 mL homogenized stool)

Physician Office/Draw Specimen Preparation

Maintain specimen frozen (-20°C/-4°F or below) prior to transport.

Preparation for Courier Transport

Transport: 5.0 grams, random stool, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL homogenized)

Rejection Criteria

Fecal collected in any preservative or fixative.

In-Lab Processing

Maintain specimen frozen (-20°C/-4°F or below) prior to transport.

Transport: 5.0 grams, random stool, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL homogenized) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal: 14 days (supernatant only)

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday – Friday.
Results available in 1-3 days.

Reference Range

Less than or equal to 54 mg/dL.

Test Methodology

Nephelometry.

Interpretation

By report.

Clinical Utility

This assay aids in the diagnosis of protein-losing enteropathy. The recommended assay for this diagnosis is the alpha-1-antitrypsin clearance (feces and serum). In the absence of a 24-hour stool collection and/or a contemporary serum specimen, the fecal concentration of alpha-1-antitrypsin can be used as a plasma marker. The clearance is preferred in order to normalize the large range of serum alpha-1-antitrypsin concentrations.

CPT Codes

82103

Contacts

Last Updated

8/12/2025