Lab Test

Alpha 1 Antitrypsin, Fecal


Test Codes

EPIC: LAB5930, Beaker: XA1AF, Mayo: A1AF


Send Outs

Specimen Collection Criteria

Collect: 5 grams random stool specimen in a sterile collection container. (Minimum: 1.0 mL homogenized stool)

Physician Office/Draw Specimen Preparation

Maintain specimen frozen (-20°C/-4°F or below) prior to transport.

Preparation for Courier Transport

Transport: 5 grams, random stool, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL homogenized)

Rejection Criteria

Fecal collected in any preservative or fixative.

In-Lab Processing

Maintain specimen frozen (-20°C/-4°F or below) prior to transport.

Transport: 5 grams, random stool, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL homogenized) 


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.


Sent to Mayo Medical Laboratories, Rochester, MN.


Monday – Friday.
Results available in 1-2 days.

Reference Range

Less than or equal to 54 mg/dL.

Test Methodology



By report.

Clinical Utility

This assay aids in the diagnosis of protein-losing enteropathy. The recommended assay for this diagnosis is the alpha-1-antitrypsin clearance (feces and serum). In the absence of a 24-hour stool collection and/or a contemporary serum specimen, the fecal concentration of alpha-1-antitrypsin can be used as a plasma marker. The clearance is preferred in order to normalize the large range of serum alpha-1-antitrypsin concentrations.

CPT Codes



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