Aldosterone, 24-Hour Urine

Test Codes

EPIC: LAB1232167, Beaker: Aldost 24U, Quest: 229

Department

Send Outs

Instructions

• A Urine Creatinine test is performed on each sample.
• Please refer to the Specimen Collection Manual for instructions on 24-Hour Urine Collection:
  • Urine 24-Hour Collection - Inpatient.
  • Urine 24-Hour Collection - Outpatient.
  • Urine 24-Hour Collection - Outreach.

Specimen Collection Criteria

Collect (preferred specimen): 24-hour urine in 24-hour urine container.

Acceptable: 24-hour urine sample with Boric Acid (10g) added at the start of collection. Boric acid may be obtained from Client Services at 800-551-0488.

• Include start and end dates and times for the collection period on the specimen container.
• The specimen must be transported to the Laboratory after the end of the collection interval.

Physician Office/Draw Specimen Preparation

Maintain unpreserved specimens room temperature (20-26°C or 68-78.8°F).

Preparation for Courier Transport

Transport: Entire preserved 24-hour urine collection at room temperature (20-26°C or 68-78.8°F).

Rejection Criteria

• Urine collected with HCl.
• Specimens not collected and processed as indicated.

In-Lab Processing

Measure total volume of 24-hour urine specimen. Record total volume and collection start and end dates and times in the LIS system. (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (with preservative) (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions. 

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Sunday, Tuesday.
Results available in 3-9 days.

Reference Range

Aldosterone, 24-Hour Urine
Random Sodium Diet

Age	mcg/24 hours
2-7 years	5.7 or less
8-11 years	10.2 or less
12-16 years	15.6 or less
Adults	2.3-21.0

Oral sodium loading test (high salt diet for 3 days): 12 mcg/24 hrs or less*

*Funder JW, Carey RM, Mantero F, et al. The Management of Primary
Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016; 101:1889-1916

Creatinine, 24-Hour Urine

<3 Years	Not established
3-8 Years	0.10-0.80 g/24 h
9-12 Years	0.20-1.40 g/24 h
13-17 Years	0.40-1.90 g/24 h
>17 Years	0.50-2.15 g/24 h

Test Methodology

Hydrolysis • Extraction • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).

Clinical Utility

Aldosterone is a hormone produced by the adrenal glands. Patients with primary hyperaldosteronism exhibit hypokalemia, hypertension, and low direct renin concentrations.

CPT Codes

82088, 82570.

Contacts

Last Updated

12/17/2025