Porphyrins and Porphobilinogen (PBG), Urine
Test Codes
EPIC: LAB8531, Beaker: XPORPBGU, ARUP: 2002181
Department
Send Outs
Instructions
- Please refer to the Specimen Collection Manual for instructions on 24-Hour Urine Collection:
- Must protect from light for entire collection.
Specimen Collection Criteria
Collect (preferred specimen): 24-hour urine sample with no preservative.
- Keep 24-hour urine specimen iced or refrigerated during collection.
- Include start and end dates and times for the collection period on the specimen container.
- All specimens must be protected from light.
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Urine Preservative Options
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No Preservative
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6N Hydrochloric Acid
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Boric Acid (10g)
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Sodium Carbonate
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50% Acetic Acid
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REQUIRED
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Unacceptable
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Unacceptable
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Unacceptable
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Unacceptable
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Physician Office/Draw Specimen Preparation
Protect specimen from light. Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.
Preparation for Courier Transport
Transport: Entire 24-hour urine collection.
Rejection Criteria
Specimens not collected and processed as indicated.
In-Lab Processing
Protect specimen from light. Measure total volume of 24-hour urine specimen. Record total volume and collection start and end dates and times in the LIS system. Aliquot 8.0 mL from the well-mixed 24-hour urine collection and freeze (-20°C/-4°F or below). (Minimum: 4.0 mL)
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 4 days
Frozen (-20°C/-4°F or below): 30 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.
Laboratory
Sent to ARUP Laboratories, Salt Lake City, UT.
Performed
Monday – Friday.
Results available in 2-5 days.
Reference Range
By report.
Test Methodology
High Performance Liquid Chromatography/Ion Exchange Chromatography / Quantitative Spectrophotometry.
Interpretation
By report.
Clinical Utility
Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Urine porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittent porphyria (AIP).
CPT Codes
84120, 84110.
Contacts
Last Updated
11/3/2023
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