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Osteocalcin (Bone G1a Protein)

Test Codes

EPIC: LAB6121, Beaker: XOSTE, Mayo: OSCAL

Department

Send Outs

Instructions

For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 0.8 mL)

Rejection Criteria

Hemolyzed specimens.

Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and freeze (-20°C/-4°F or below).

Transport: 1.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Minimum: 0.8 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 90 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday – Friday
Results available in 2-4 days.

Reference Range

By report.

Test Methodology

Quantitative Electro Chemiluminescent Immunoassay.

Interpretation

In patients with renal failure the osteocalcin result can be elevated, both directly, due to impaired clearance, and indirectly, due to renal osteodystrophy.

Clinical Utility

This assay is used to evaluate bone disease. Increased levels of osteocalcin are found in bone diseases characterized by increased bone turnover. Osteocalcin levels are elevated in Paget's disease of the bone, cancer accompanied by bone metastases, primary hyperparathyroidism and renal osteodystrophy. Osteocalcin levels may be a useful index in evaluating the therapeutic management of patients.

CPT Codes

83937

Contacts

Last Updated

10/8/2023