Propafenone Level, Serum

Rythmol

Test Codes

Order Miscellaneous Send Out, Beaker: XMISC, MAYO: PFN

Department

Send Outs

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes.
Time of Collection: Samples should only be collected after patient has been receiving propafenone for at least 3 days. Draw trough, just prior to the next dose.

Physician Office/Draw Specimen Preparation

Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

In-Lab Processing

Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 28 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinical Laboratory, Rochester, MN.

Performed

Monday – Saturday
Results available in 3-6 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Mass Spectrometry (LC-MS/MS).

Interpretation

The therapeutic concentration is 0.5 to 2.0 mcg/mL; concentrations below 0.5 mcg/mL likely indicate inadequate therapy and propafenone above 2.0 mcg/mL indicates excessive therapy.

Clinical Utility

Propafenone is used for the treatment of ventricular arrhythmias (ventricular tachycardia, supraventricular tachycardia, and ventricular premature contractions). This assay is used for the therapeutic monitoring and toxicity assessment of propafenone.

CPT Codes

80299

Contacts

Last Updated

1/3/2025