Lab Test

Propafenone Level


Test Codes

Antrim #17065, EPIC: LAB5413, SOFT: PROPF

Specimen Collection Criteria

Collect: One plain Red-top tube. (Minimum Whole Blood: 2.0 mL)

Do not use Serum Separator Tubes.
Time of Collection:
 Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.

Physician Office/Draw Specimen Preparation

Let specimens clot 30-60 minutes. Refrigerate (2-8°C or 36-46°F) the collection tube within two hours of collection. (Minimum: 2.0 mL blood)

Preparation for Courier Transport

Transport: Collection tube, refrigerated (2-8°C or 36-46°F). (Minimum: 2.0 mL blood)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Severely lipemic or hemolyzed specimens.  

In-Lab Processing

Let specimens clot 30-60 minutes. Centrifuge specimen to separate serum from cells. Deliver an aliquot of serum or the collection tube immediately to the appropriate testing station.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 2 months


Royal Oak Toxicology Laboratory


Tuesday, Friday.
Results available the same day as testing performed (1-5 days).

Reference Range

Therapeutic Range: 0.50-2.00 mcg/mL.
Critical Value: Greater than 2.5 mcg/mL.

Test Methodology

High Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.


This assay measures total Propafenone concentrations in serum. Propafenone is a type Ic antiarrhythmic drug (Vaughn Williams Scheme), exhibiting both slow sodium blockade, and, at higher concentrations, beta blockade. Beta blockade activity is predominately from the (S)-enantiomer of Propafenone. This assay does not distinguish between the (S)- and (R)-enantiomers, but measures the sum of their individual concentrations.

Clinical Utility

Propafenone is used for the treatment of ventricular arrhythmias (ventricular tachycardia, supraventricular tachycardia, and ventricular premature contractions). This assay is used for the therapeutic monitoring and toxicity assessment of propafenone.

CPT Codes



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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.