Lab Test

Products of Conception Karyotype

Chromosome Testing, Karyotyping, Chromosome Analysis, Karyogram, POC

Test Codes


Specimen Collection Criteria

Collect: Tissue placed in a sterile, leak proof container containing sterile saline, Ringer's lactate solution, or tissue culture medium.

  • Specimens should be obtained by an Obstetrician under sterile conditions.
  • Preferred tissues for Cytogenetic studies are chorionic villi, amnion, placenta, fascia, non-macerated internal organs, and fetal skin with dermis. Obtain more than one tissue type, when possible, to increase chances of successful cultures.
  • A copy of the requisition must be sent with the specimen. The specimen and requisition form should be placed in a sealed transport bag. The requisition form should contain the patient name, birth date, medical record number, requesting physician, specimen type and test requested, date and time of collection, and tentative diagnosis.

Physician Office/Draw Specimen Preparation

Do not freeze specimen. Maintain specimens at room temperature (20-25°C or 68-77°F) prior to courier pickup. For delays in transport (greater than 24 from the time of collection), refrigerate (2-8°C or 36-46°F) the specimen.

Preparation for Courier Transport

Transport: Tissue in sterile saline, Ringer's lactate solution, or tissue culture medium, at room temperature (20-25°C or 68-77°F) or refrigerated (2-8°C or 36-46°F).

Rejection Criteria

  • Specimens arriving in the Laboratory 4 days or more following the original collection date.
  • Fixed or frozen specimens.
  • Specimens arriving contaminated or suboptimal specimens (i.e. fat tissue, blood clots, severely macerated/necrotic tissue).

Inpatient Specimen Preparation

Transport specimens to the Laboratory immediately after collection for processing.

In-Lab Processing

Specimens are processed immediately upon receipt in the Cytogenetics Laboratory.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 96 hours
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days. A backup culture is maintained for two weeks past sign-out of the final report.


Royal Oak Cytogenetics Laboratory


Monday – Friday, 8:00 am – 5:00 pm.
Results available within 14-21 days of receipt in the Laboratory.

Reference Range

Normal results would be 46,XX or 46,XY with no apparent abnormalities present.

Test Methodology

High-resolution microscopic analysis of chromosomes to provide a digital image karyotype. Special stains or techniques such as C-Banding, NOR Banding, DAPI, Q Banding and FISH may be required to further identify specific chromosomal abnormalities or variants.


Based on completion of chromosomal analysis. Interpretation will be issued in the form of a final report.

Clinical Utility

Karyotyping (chromosome analysis) is performed on prenatal specimens to determine the presence of fetal chromosomal abnormalities. Cytogenetic testing may be performed for a wide variety of reasons such as multiple miscarriages, family history of genetic abnormalities, abnormal ultrasound, small for gestational age, or intrauterine growth retardation.

Clinical Disease

Abnormal karyotype results should be followed up with Genetic Counseling.

CPT Codes

88233, 88262, 88280.


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.