Lab Test

Porphyrins & Porphobilinogen, Urine Qualitative

Porphobilinogen, Qualitative Urinary

Test Codes

Antrim #15648, SOFT: PORPG, EPIC: LAB5873

Specimen Collection Criteria

Collect (preferred specimen): Random urine specimen in a screw-capped container (preferred) or other sterile collection cup. (Minimum Volume: 20 mL)

  • It is advisable NOT to use the first voided morning specimen, or specimens obtained following excessive fluid intake.
  • Protect specimen from light.
  • Transport specimen to the Laboratory immediately for processing.
  • Record the exact time of specimen collection on the cup or in the computer system.

Physician Office/Draw Specimen Preparation

Protect specimen from light. Maintain specimens refrigerated (2-8°C or 36-46°F). (Minimum: 20 mL)

Preparation for Courier Transport

Transport: Light-protected urine in a sterile collection cup, refrigerated (2-8°C or 36-46°F). (Minimum: 20 mL)

Rejection Criteria

Specimens not protected from light.

Specimens not collected and processed as indicated.

Inpatient Specimen Preparation

Protect specimen from light. Transport to the Laboratory immediately for processing.

In-Lab Processing

Protect specimen from light. All specimens must be frozen (-20°C/-4°F or below) upon receipt in the Laboratory. The urine should be returned to room temperature (20-26°C or 68-78.8°F) and thoroughly mixed before testing.

Storage

Specimen Stability for Testing:

Porphyrins
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 month

Porphobilinogen
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 2 days
Frozen (-20°C/-4°F or below): 1 month

NOTE: Urine Porphobilinogen only stable for 48 hours unless frozen.

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Monday, Wednesday, Friday.
Results are available in 2-4 business days.

Reference Range

Negative.

Test Methodology

Ion Exchange Resin Column.

Interpretation

It is suggested that a positive result be followed up by collecting a 24 hour urine for quantitation of urinary porphyrins. This test includes porphobilinogen and should assist in diagnosing the specific type of porphyria.

Porphobilinogen is usually present in the urine in an acute attack intermittent porphyria, hereditary coproporphyria, variegate porphyria or porphobilinogen synthase deficiency.

Note: A porphyrin test is run with each ordered porphobilinogen.

Clinical Utility

The detection or porphyrias.

CPT Codes

84106.

Contacts

Last Updated

5/20/2020

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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.