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Platelet Associated Antibodies

PAIg, Anti Platelet AB, Flow Cytometry, Platelet Associated Antibody Assay, Platelet Antibody Direct

Test Codes

EPIC: LAB6910, Beaker: XPLAB, Warde: PLABD

Department

Send Outs

Specimen Collection Criteria

Collect: Three Lavender-top EDTA tubes.

Physician Office/Draw Specimen Preparation

Do not centrifuge. Do not refrigerate or freeze. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: 10.0 mL whole blood, at room temperature (20-25°C or 68-77°F). (Minimum: 5.0 mL adult, 1.0 mL pediatric)

Rejection Criteria

• Centrifuged specimens.
• Specimens that have been refrigerated or frozen.
• Specimens not collected and processed as indicated.

In-Lab Processing

Do not centrifuge. Do not refrigerate or freeze. Maintain whole blood at room temperature (20-26°C or 68-78.8°F) prior to transport.

Transport: 10.0 mL whole blood, at room temperature (20-26°C or 68-78.8°F). (Minimum: 5.0 mL adult, 1.0 mL pediatric) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 6 days
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Warde Medical Laboratory, Ann Arbor, MI, forwarded to Quest Diagnostics Nichols Institute, San Juan Capistrano, CA.

Performed

Sunday – Saturday.
Results available in 4-6 days. 

Reference Range

Anti-IgG: Negative.

Test Methodology

Flow Cytometry.

Interpretation

By report.

Clinical Utility

The clinical application of this assay is in the diagnosis of immune-mediated thrombocytopenia (ITP), therapeutic monitoring of ITP patients, and in the assessment of alloimmunization of patients receiving multiple platelet transfusions. Increased amounts of immunoglobulin (Ig) on platelet surfaces may lead to their premature destruction. The binding of antiplatelet antibodies is suspected in several disorders including pregnancy-associated thrombocytopenia, ITP, drug-induced thrombocytopenia, lymphoma and HIV infection.

CPT Codes

86023

Contacts

Last Updated

11/3/2023