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Pancreatic Polypeptide

Test Codes

EPIC: LAB6313, Beaker: XPANP, Mayo: HPP

Department

Send Outs

Instructions

Patients must be fasting for 8 hours prior to specimen collection.

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube.

• Collect specimen on ice.
• Send specimen for processing immediately after collection.

Physician Office/Draw Specimen Preparation

Critical frozen. Centrifuge to separate plasma from cells. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 3.0 mL plasma, frozen (-20°C/-4°F or below). (Minimum: 0.35 mL)

Rejection Criteria

• Lipemic specimens.
• Grossly hemolyzed specimens.
• Specimens not collected and processed as indicated.

Inpatient Specimen Preparation

Critical frozen. Deliver specimen, on ice, to the Laboratory immediately after collection.

In-Lab Processing

Critical frozen. Centrifuge to separate plasma from cells. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Transport: 3.0 mL plasma, frozen (-20°C/-4°F or below). (Minimum: 0.35 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 90 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Sunday and Tuesday.
Results available in 4-9 days.

Reference Range

By report.

Test Methodology

Radioimmunoassay (RIA).

Clinical Utility

Pancreatic Polypeptide (PP) is secreted by the pancreas in response to hypoglycemia, ingestion of "sham" feeding (food chewed, but not swallowed) secondary to vagal nerve stimulation. Secretion is blocked by vagotomy or atropine.

The exact physiological role of PP is undetermined, although the hormone is thought to be involved in exocrine pancreatic secretion and gallbladder empyting.

Markedly elevated levels are often associated with endocrine tumors of the pancreas (e.g. insulinoma, glucagonoma, PPoma, vipoma). Patients with diabetes prolonged fasting may also have elevated PP levels.

A normal response to sham feeding consists of a rapid Pancreatic Polypeptide rise over baseline followed by a return to baseline. With vagal damage no increase over baseline is seen.

CPT Codes

83519

Contacts

Last Updated

11/3/2023