Lab Test

Pancreatic Elastase 1 (E1) in Stool

Fecal Elastase, E1

Test Codes

MAYO: FPAN1, EPIC: LAB6122, SOFT: XPE1F

Specimen Collection Criteria

Collect: Random stool specimen in a sterile collection container without preservatives.

  • Watery stools are not recommended for this assay due to the dilutions made during the assay. A formed stool is requested for testing to get accurate results.
  • Pancreatic enzyme supplementation therapy should bve discontinued prior to collection.

Physician Office/Draw Specimen Preparation

Refrigerated (2-8°C or 36-46°F) specimen after collection and prior to transport.

Preparation for Courier Transport

Transport: Stool specimen, Refrigerated (2-8°C or 36-46°F). (Minimum: 0.3 g)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Refrigerated (2-8°C or 36-46°F) specimen after collection and prior to transport.

Transport: Stool specimen, Refrigerated (2-8°C or 36-46°F). (Minimum: 0.3 g) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Laboratories, Rochester, MN, forwarded to Quest Diagnostics, San Juan Capistrano, CA.

Performed

Sunday, Tuesday, Thursday.
Results available 5-11 days.

Reference Range

Normal: Greater than 200 mcg Elastase/g stool. 
Moderate to slight exocrine pancreatic insufficiency: 100-200 mcg Elastase/g stool.
Severe exocrine pancreatic insufficiency: Less than 100 mcg Elastase/g stool.

Test Methodology

Immunoassay (IA).

Interpretation

There are no known factors which interfere with this assay.  In particular, enzyme substitution therapy does not influence the determination of elastase 1. 

Watery stools are not recommended for this assay due to the dilutions made during the assay. A formed stool is requested for testing to get accurate results.

This test determines the concentration of pancreatic elastase 1 (E1) in a fecal specimen. Pancreatic elastase 1 (E1) is not degraded during intestinal transit and therefore reflects exocrine pancreatic function directly.

Clinical Utility

Quantifying elastase 1 (E1) can help in the diagnosis or exclusion of pancreatic exocrine insufficiency, which can be caused by chronic pancreatitis, cystic fibrosis, or diabetes mellitus.

CPT Codes

82656

Contacts

Last Updated

3/31/2020

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This directory currently reflects information only for specimens collected and/or processed at the
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