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Liver / Kidney Microsome Type 1 Antibody, IgG

P450 2D6 Antibody

Test Codes

EPIC: LAB6086, Beaker: XLKM, Warde: LKMAB

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

• Lipemic specimens.
• Grossly hemolyzed specimens.
• Heat-treated Specimens.
• Microbally contaminated specimens.
• Plasma
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 21 days
Frozen (-20°C/-4°F or below): Undetermined

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Warde Medical Laboratory, Ann Arbor, MI.

Performed

Monday – Friday.
Results available in 2-5 days.

Reference Range

Negative: Less than or equal to 20.0 Units.
Equivocal: 20.1 - 24.9 Units.
Positive: Greater than or equal to 25.0 Units.

Test Methodology

Enzyme Immunoassay (EIA).

Interpretation

LKM (liver kidney microsome) autoantibodies are found in a subgroup of patients with ANA-negative autoimmune chronic active hepatitis. Antibody to hepatitis C virus can be found in about 50% of patients with low LKM autoantibody titers.

Antibodies to liver kidney microsome antigens (anti-LKM1) occur in a subset of patients with chronic autoimmune hepatitis. These patients have a high frequency of associated immunologic disorders and an absence of non-organ specific autoantibodies (smooth muscle antibodies). Most patients with type of chronic autoimmune hepatitis are children.

Clinical Utility

This assay is used to detect a clinically specific antibody in patients with autoimmune chronic hepatitis (type 2).

CPT Codes

86376

Contacts

Last Updated

4/23/2024